You seem to think to know what is the appropriate network config file and how to configure there. How do you think we can check if you are correct in these assumptions if you do not tell us exactly which file and what you put there?
It can be configured via the NM connection-editor, or directly in the configuration files which are located in /etc/NetworkManager/system-connections/ directory. For example, if MTU is set manually (say 1522 bytes), it will appear in the connection definition like this
Have you verified that your hardware NIC supports the size jumbo frames you’re trying to configure?
And, is your physical network connection point to point or have verified that all intermediate devices like switches similarly support the size you’re trying to configure?
Also, FYI
Although Jumbo Frames is a Layer 2 implementation to transfer super sized packets,
Another way to greatly increase throughput is to modify Layer 3 Window Scaling.
This is mentioned briefly with little comment along with other configurable network options in the community openSUSE docuementation https://doc.opensuse.org/documentation/leap/tuning/html/book.sle.tuning/cha.tuning.network.html