Can't configure Wine on Leap 16.0

There are a quite some threads in the forum regarding this topic…
Leap 16 removed 32bit support (see relase notes). To enable it you need to:

sudo update-bootloader --add-option ia32_emulation=1
sudo update-bootloader --config

Reboot.

And if you use SELinux:

sudo zypper in selinux-policy-targeted-gaming