Passthrough Xen with dedicated GPU is as close as to native performance as you’re going to get, we’re talking almost 100% native speeds because the underlying OS uses the GPU directly (hence it’s called passthrough) - however you need 2 GPUs for that to work.
Tested it with a 680x2 and… let’s just say, it’s fast 
It’s pointless to install 32bit version unless you have old hardware. openSUSE comes with multiarchitecturs and so does wine. When you run WINE on 64bit system you should first define a prefix and its architecture eg.:
export WINEPREFIX=/home/xxx/wineprefixes/wow32
export WINEARCH=win32
winecfg (and choose win7)