I have downloaded wine but can not figure out how to run something with it. Any help would be appreciated
It pretty easy, in konsole just type “wine notepad.exe” for instance, for furterer options check WineHQ - Documentation
You didn’t mention if you were using KDE or Gnome, but I know this works in KDE and might work in Gnome.
Browser to the application (.exe) in the file browser, rightclick, open with
Type in wine and hit ok.
Or what I do mostly (Dolphin / KDE4) hit f4 in the folder with the file to bring up the console and type wine applicationname there (what arcull suggested)