Hi
Is python3-wxPython installed, does POL support python3, python2 is deprecated from Tumbleweed…
I see (well 19 days ago) they added python3 support as well as removing the deprecated wxversion and moved to wxPyhton
https://github.com/PlayOnLinux/POL-POM-4
https://github.com/PlayOnLinux/POL-POM-4/commit/e5c5a26fc56679ea91341e6c116d585d89175546
I would suggest a bug report to update to version 4.4 which would fix the issue (released 13 days ago) in Tumbleweed;