Still got a couple of suggestions, try this first :
setup-pulseaudio --disable
Then try alsamixer again and see if it keeps the changes. When done with volume control, run this as root :
alsactl store
There’s also a wine regedit setting for audio driver, more info here.
+-Drivers
| |
| +->Audio
| Which audio backend to use. Should be a string such as "alsa" or "oss" or "coreaudio".
| Set to the empty string to disable audio entirely. Given a comma-separated list of
| drivers, Wine will attempt to make the most appropriate choice.