Do you install opensource or proprietary drivers?
Just saying what i did with mine.
I’m using a R7 250X (Sapphire VaporX 1gb 128 bit ) with proprietary drivers,with a dual monitor config ( actually is a philips 19 inch vga thorugh adapter vga–>dvi and a sony bravia 32 inch connected through HDMI 1.4) and i have no troubles.
And I’m using an AMD A10 6800 4 core BE (the 4.4 Mhz version) as CPU.