I use the Kensington Expert Mouse. openSUSE 13.1
I tired of looking at the page I’m working on scrolling in the “wrong direction”. The scroll wheel did indeed pull the scroll bar in the right direction but that’s inverted to the page view.
Rotating the scroll wheel down to move the page up doesn’t work for me.
If you find you don’t like it, swap the out of order numbers back to normal counting sequence.
So here’s the fix:
echo "pointer = 1 2 3 5 4 7 6 8 9 10 11 12" > ~/.Xmodmap && xmodmap ~/.Xmodmap
H/T http://andym3