As the subject says, I need a bit of help. It is a bit off topic, which is why I am posting here. I am researching how to calculate insulin cascade, but can’t find like equations. I find papers talking about it, just no equations. This would be especially helpful for a program I am developing Diabetic Assistant Support site Even with out the program, it would still help me, and others, so that maybe we don’t crash (low blood sugar). Any help would be appreciated.
So this is also way off of anything I understand, but I found this document you might look at:
http://www.math.utah.edu/~gustafso/f2009/2250mapleL10-F2009.pdf
Thank You,
No. Thank you! So far, that’s the closest I have seen. Not sure how you found it, but thanks.
I forgot to say, that if anyone else has more information on this, more equations, I by no means consider this matter closed. So more input is welcome.
I am rather conscious that i could be doing exactly the wrong thing…providing you with another source of distraction when it might be better to let you get on with the information that you have at your disposal.
On seeing the initial question, my first thought was ‘…that ought to be rather easy…’. That thought stayed around for a microsecond or two before being replaced by the more sensible ‘…and here are the reasons why it won’t be…’. My suspicion is that, at every stage of the cascade there are a number of factors that influence efficiency (nutrition, fitness as general ones and specific enzyme statuses as derived factors) and that means that producing generalised equations (valid for a population of individuals) is going to be tough. Having said that, for a particular individual, at a particular stage in the progression, things should be easier.
Now having finished the general disclaimers for someone who doesn’t know enough, try looking at this (Systems Analysis of the Glucose Signalling Pathway, if the Google Books link doesn’t work for you), where some of the variability stuff is discussed in more detail. I am afraid I just skimmed the document, but you will probably have more determination.
I appreciate it. I already came across that link, good information, but I didn’t see any equations. I must have missed it.
As to the other points you made, I have found some partial derivatives on modeling insulin therapies; http://userweb.port.ac.uk/~makroglo/athena/projects/Geraghty/Geraghty_proj_08.pdf and also on metabolic rate Basal metabolic rate - Wikipedia, the free encyclopedia
I have been researching this, for this program anyway for about a year or so, before this idea for this program, about 3/1/2 years, give or take a few months. I’ve only been a diabetic for 4 years. So I got into the research fast. Especially when I found my doctors were inept and not much help. My former primary care doctor over rated himself and tried taking me on cause he thought he could manage it…wrong. I finally get an endocrinologist, and wile she helps me get on the pump, she does little else. I used to see a pharmacologist, trained in diabetes, and I quickly earned her respect in the knowledge I demonstrated, the same was true to the nutritionist and diabetic educator. They all kinda left me alone because they could see I already knew it. Not that I know it all, quite obviously, or I wouldn’t have asked. Just that I have done the homework, and know quite a bit.
Was diagnosed as being diabetic the 1st of September of this year, after almost dying 
so I will be following this thread with interest 
Best of luck Jonathan_R!
Regards
Neil
I feel for you. I remember what it was like for me, when I got diagnosed. You can read about it here. It was my struggle that lead me to do all this, but then you can read all that for yourself.
I can honestly say I feel for you too… My story is very similar to yours, age about the same, no history, eye sight, urinating etc. In the middle of the summer in the UAE of all places I had been Ketoacidosis (DKA) for about a month before going to see a doctor (fasting blood sugar was 970 when I hit the hospital, sugar in my veins rather than blood)…
I do have it under contol (ish)… I take insulin twice a day and some other pills and as long as I eat 6 times a day I minimize the shaky feeling (sugar drops to about 60 then its definitely food time)…
Again, I hope you get this done and it assists you and all the others like us that have to live with this…
Regards
Neil
I’m a diabetic too guys!
Regards Thanasis
Just an update.
Now the source packages are ready for me to build. I just have to learn how to build rpm’s 
While it is open source, it is not free as in cost. See here for details We Are Unique Main Site
I’ve been a Diabetic for 10 years. I wear an insulin pump and have just started wearing a CGMS (continuous glucose monitoring system ) for the past 2 months.
The CGMS has been very helpful with detecting low blood sugars before they too low.
Good luck!
Hiatt