Here’s a detailed, easy-to-follow tutorial on how to setup openSUSE server that offers all services needed by ISPs and hosters.
These include:
Apache web server (SSL-capable)
Postfix mail server with SMTP-AUTH and TLS
BIND DNS server
Proftpd FTP server
MySQL server
Dovecot POP3/IMAP
Quota
Firewall
…
…
nginx is pretty vanilla and I see no reason why it wouldn’t work on openSUSE. So any experiences you read about nginx on other Linux distros would apply to openSUSE too. Of course you may have to do kernel tuning for your workload.