What is SETI@home?
“SETI@home is a scientific experiment that uses Internet-connected computers in the Search for Extraterrestrial Intelligence (SETI). You can participate by running a free program that downloads and analyzes radio telescope data.”
while i know it is cool to seek “little green men”, i think it is MORE
KEWL to attack the aliens likely to actually invade someone you are
close to…maybe a mom/dad, sister/brother, daughter/son, neighbor, etc…
take a look at http://folding.stanford.edu/
and instead of little green men, work to kill off many well known
diseases, such as Alzheimer’s, Mad Cow (BSE), CJD, ALS, Huntington’s,
Parkinson’s disease, and many Cancers and cancer-related syndromes.
oh, and they are NICE, in that they just use UNneeded cycles…i can
feel absolutely NO difference in my system’s responsiveness or speed if
the client is running or not!
think about it–i’ve never seen a little green man, but both my mom and
wife died of cancer…will yours?
DenverD wrote:
> while i know it is cool to seek “little green men”, i think it is MORE
> KEWL to attack the aliens likely to actually invade someone you are
> close to…maybe a mom/dad, sister/brother, daughter/son, neighbor, etc…
>
> take a look at
> http://folding.stanford.edu/
> and instead of little green men, work to kill off many well known
> diseases, such as Alzheimer’s, Mad Cow (BSE), CJD, ALS, Huntington’s,
> Parkinson’s disease, and many Cancers and cancer-related syndromes.
>
> Folding@home has 32 and 64 bit linux clients at:
> http://folding.stanford.edu/English/Download
>
> oh, and they are NICE, in that they just use UNneeded cycles…i can
> feel absolutely NO difference in my system’s responsiveness or speed if
> the client is running or not!
>
> think about it–i’ve never seen a little green man, but both my mom and
> wife died of cancer…will yours?
>
> DenverD
Both projects have there merits, just cause you haven’t seen “little
green men” doesn’t mean we are the only “intelligent” life in the
universe. As technology advances we are finding more and more earth-like
planets that might be able to sustain life.
> Both projects have there merits, just cause you haven’t seen “little
> green men” doesn’t mean we are the only “intelligent” life in the
> universe.
i didn’t say, nor intend to even try to persuade anyone that we are…
> As technology advances we are finding more and more earth-like
> planets that might be able to sustain life.
so? should we take our unsolved diseases with us when we go there?
of course ALL are free to run anything on their computer…i just happen
to believe it nice to know that seti@home is only ONE (and NOT the
largest) of many many distributed computing projects/clients
available…see:
SETI has gone through their entire spectrum multiple times and not found anything. They have also squanded resources, and the merit of their project is debatable.
I’d love to see contact with intelligent life, but the merit of Folding@Home isn’t so debatable. Protein folding provides real benefits to disease research today.
I know Baker and Ranganathan and their work very well and (like the rest of the protein community) find their work very important and impressive. However, Rosetta@home and Folding@Home are addressing very different problems.
Rosetta only predicts the final folded state, not how do proteins fold (and Rosetta has nothing to do with protein misfolding). Thus, those methods are not useful for the questions we're interested in and the diseases we're tackling (Alzheimer's Disease and other aggregation related diseases).
Also, one should note that accurate computational protein structure prediction is still very challenging compared to what one can do experimentally, whereas the information obtained from Folding@home on the nature of folding and misfolding pathways matches experiment (e.g. with quantitative validation in rates, free energy, etc) and then goes beyond what experiment can tell us in that arena. While Rosetta has gone a long way and is a very impressive project, given the choice between a Rosetta predicted structure and a crystal structure, one would always choose the crystal structure. I bet that will be changing due to their great efforts, but that may still be a ways off for that dream to be realized.
So, both are valuable projects IMHO, but addressing very different questions. I think there are some misunderstandings out there, though. Some people think FAH is all about structure prediction (which it is not -- that's Rosetta's strength) and some think Rosetta is about misfolding related disease (which it's not, that's Folding@Home's strength). Hopefully this post helps straighten some of that out.