OPs problem might be this
# zypper dup
Retrieving repository 'openSUSE Tumbleweed Oss' metadata ............................................................................................................................[done]
Building repository 'openSUSE Tumbleweed Oss' cache .................................................................................................................................[done]
Retrieving repository 'openSUSE Tumbleweed Non-Oss' metadata ........................................................................................................................[done]
Building repository 'openSUSE Tumbleweed Non-Oss' cache .............................................................................................................................[done]
Retrieving repository 'Packman openSUSE Tumbleweed' metadata ........................................................................................................................[done]
Building repository 'Packman openSUSE Tumbleweed' cache .............................................................................................................................[done]
Loading repository data...
Reading installed packages...
Warning: You are about to do a distribution upgrade with all enabled repositories. Make sure these repositories are compatible before you continue. See 'man zypper' for more information about this command.
Computing distribution upgrade...
3 Problems:
Problem: the installed python310-PyQt6-6.3.1-1.3.x86_64 requires 'libQt6Core.so.6(Qt_6.3.2_PRIVATE_API)(64bit)', but this requirement cannot be provided
Problem: the installed calibre-6.5.0-1.1.x86_64 requires 'libQt6Gui.so.6(Qt_6.3.2_PRIVATE_API)(64bit)', but this requirement cannot be provided
Problem: the installed python310-PyQt6-6.3.1-1.3.x86_64 requires 'libQt6Core.so.6(Qt_6.3.2_PRIVATE_API)(64bit)', but this requirement cannot be provided
Problem: the installed python310-PyQt6-6.3.1-1.3.x86_64 requires 'libQt6Core.so.6(Qt_6.3.2_PRIVATE_API)(64bit)', but this requirement cannot be provided
deleted providers: libQt6Core6-6.3.2-1.2.x86_64
Solution 1: deinstallation of python310-PyQt6-6.3.1-1.3.x86_64
Solution 2: keep obsolete libQt6Core6-6.3.2-1.2.x86_64
Solution 3: break python310-PyQt6-6.3.1-1.3.x86_64 by ignoring some of its dependencies
Choose from above solutions by number or skip, retry or cancel [1/2/3/s/r/c/d/?] (c):
I saw it just a minute ago on openSUSE Tumbleweed 20220930.