I have compiled WINE by hand on x86_64 - but just as a side project to see if I could do it.
However, certain features end up not working, like libgphoto for instance, because of missing 32bit runtime development files for x86_64 (32bit development files were not meant to be included on x86_64.)
Nope. But You do need many of the 32bit-devel packages; and you need to make soft links to make up for missing 32bit-devel packages that aren’t included - as mentioned at WineOn64bit - The Official Wine Wiki
Oh. I just realized this is missing under the SUSE section: You need to configure the source with the following settings (only for x86_64):