If you get the error "Callee RC: NS_ERROR_FACTORY_NOT_REGISTERED
(0x80040154)"
Try starting it from a console ( *VirtualBox*, captalised V and B ).
Probably comes up with something like:
Wrong owner (0) of '/tmp/.vbox--username--ipc'.
Wrong owner (0) of '/tmp/.vbox--username--ipc'.

*sudo rm -R /tmp/.vbox** to remove the files, and they'll be recreated
the next time you start virtualbox with the proper permissions.

Thought I'd share how to solve it as all the google results seem to
spawn several pages before a solution is provided, granted one is even
provided.
Bit too short for the how-to forum, so that's why here in
Applications.
(For other problems make sure you've added yourself to the vboxusers
group)


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